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KMID : 1101420180500030217
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Korean Journal of Clinical Laboratory Science
2018 Volume.50 No. 3 p.217 ~ p.224
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Histological Evaluation of Bioresorbable Threads in Rats
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Lee Chang-Gun
Jung Jae-Yun
Hwang Sam-Noh
Park Chan-Oh
Hwang Soon-Jae
Jo Min-Jeong
Sin Min-Hi
Kim Hyun-Ho
Rhee Ki-Jong
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Abstract
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Thread lifting has become popular as a minimally invasive technique for facial rejuvenation. Commercially available threads are composed of poly-L-lactic acid (PLLA), polycaprolactone (PCL), or polydioxanone (PDO). However, the histological changes that occur in response to implanted threads are unclear. The aim of this study was to evaluate histological changes that occur in response to implantation with three types of bioresorbable threads (PLLA, PCL, PDO) in rat skin. PLLA, PCL and PDO threads were implanted in the dorsal skin of Sprague Dawley rats and tissue samples were harvested 2, 4, 8 and 12 weeks post-implantation. To evaluate histologic changes induced by bioresorbable face-lifting threads, tissue samples were stained with hematoxylin & eosin, Masson’s trichrome stain and Herovici’s collagen stain. All three threads induced neocollagenesis of type 3 collagen in the rat skin. The amount of collagen induced by the threads was dependent on the thread surface area. The PDO cavern-type thread was most effective in inducing neocollagenesis due to its extensive surface area. Our results suggest that type 3 collagen induced by bioresorbable threads depends on the thread surface area to uphold the dermis and contributes to facial rejuvenation.
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KEYWORD
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Collagen, Polydioxanone, Rat, Skin
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